Tranexamic acid: current use in obstetrics, major orthopedic, and trauma surgery

In this Continuing Professional Development module, we review the practical pharmacology of tranexamic acid and its clinical use in trauma, obstetrics, major orthopedic surgery. Tranexamic is a synthetic drug that inhibits fibrinolysis. Multiple trials various settings have shown it can reduce blood loss, transfusion rates, bleeding-associated mortality. trauma obstetrical bleeding, early administration (< three hours) may greater benefits. Overall, appears safe with no significant increase thromboembolic or seizure events. Nevertheless, current evidence has limitations related to wide heterogeneity dose, route, timing administration, as well generalizability large-scale trial findings higher income nations. an efficacious pharmacological-based conservation technique management clinically hemorrhage. All anesthesiologists should good understanding pharmacotherapeutic properties perioperative role therapy both inside outside operating room. The likely continue rise endorsement by guidelines healthcare organizations. Further quantitative research needed evaluate optimal dosing efficacy these scenarios.